Techniques and suggestions for drawing clear lines

I am looking forward to knowing how to draw clear lines by using pen tablets , I know that vector applications such as illustrator draw clear lines but I think they aren't enough comfortable as Photoshop when you use pen tablet. so I have question that when u use pen tablet for drawing Do u set setting to draw clear lines ? and what is your software suggestions (illustrator , Photoshop , sketchbook and ...)?

This is drawn by Photoshop using pen tablet. you can see that lines aren't clear.

This is drawn by Illustrator Using pen tools () not pen tablet ,but lines are clear.